Polynucleotides (PN) composition are natural, highly purified DNA molecules extracted from trout, salmon or other fish gonads. Polynucleotides are widely distributed in the human body and exist physiologically in the extracellular environment. They readily bind to water molecules and act as free radical scavengers. The polynucleotide (PN) containing products not only improve the skin hydration, but provide the trophic effects on the fibroblasts.